As AI decouples intelligence from consciousness, as XR technologies transform perception, and as matter becomes machine manipulable, three key questions about the future arise: 1) what will newer AI-infused experiential interfaces look like where digital bits occupy space and algorithms have faces, 2) what can we learn about human behavior through human-AI interaction and how can AI models learn from human behavior, and 3) how will a shift from data-centric to human-centric AI systems augment our capabilities and enrich our lives? To answer these questions, our current work focuses on Human-Computer Interaction (HCI), eXtended Reality (XR) and Human-Centered Artificial Intelligence (AI). In particular, we investigate the design, engineering and study of novel interfaces, interactions, tools and systems that focus on psychomotor skill acquisition, task guidance and creative collaboration.