Volkmann’s research focuses on the development and application of innovative new computational, artificial intelligence, and data science tools to bridge information between the atomic and cellular scales, covering more than six orders of magnitude from Ångstroms to tens of microns. Central to this effort is the analysis and interpretation of data from electron cryo-microscopy and cellular electron cryo-tomography. These two rapidly emerging methodologies offer the possibility of not only linking these scales through correlative studies with other techniques such as light microscopy and X-ray crystallography, but also to create three-dimensional mappings of entire cellular proteomes, including direct in-situ study of molecular interactions and structure at the near-atomic scale in cryogenically preserved, unstained and unprocessed cells and tissues.